Molecular Mechanism of EGFR-TKI Resistance
نویسندگان
چکیده
منابع مشابه
EGFR/Met association regulates EGFR TKI resistance in breast cancer
Breast cancers show a lack of response to epidermal growth factor receptor (EGFR) tyrosine kinase inhibitors (TKIs), despite 30% of tumors expressing EGFR. The mechanism of this resistance is unknown; however, we have recently shown that Met kinase activity compensates for loss of EGFR kinase activity in cell culture models. Met has been implicated in the pathogenesis of breast tumors and there...
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pISSN 2383-7837 eISSN 2383-7845 © 2018 The Korean Society of Pathologists/The Korean Society for Cytopathology This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/ by-nc/4.0) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work...
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ژورنال
عنوان ژورنال: Haigan
سال: 2009
ISSN: 1348-9992,0386-9628
DOI: 10.2482/haigan.49.939